NFA, our Danish member institute, published an interesting paper on Musculoskeletal Disorder and Physical Workload.
Abstract
The intricate relationship between muscle strength and mortality, particularly regarding cancer mortality, has been marked by conflicting findings. This study sets out to delve into the dose-response link between objectively measured handgrip strength and the risks associated with both all-cause and cancer mortality. Utilizing data gathered from numerous waves of the Survey of Health, Ageing, and Retirement in Europe encompassing 27 European nations and Israel, the study encompasses a substantial sample size. It includes 54,807 men (45.2%) contributing to 128,753 observations and 66,576 women (54.8%) contributing to 159,591 observations, with men averaging 64.0 years (SD 9.6) and women 63.9 years (SD 10.2). Statistical analyses were conducted through Cox regression and the Fine-Grey sub-distribution method. Over a comprehensive follow-up period totaling 896,836 person-years, the fully adjusted model unveiled a marked reduction in risk estimates for all-cause mortality among participants positioned within the upper third of handgrip strength when contrasted with the reference group. This held true for both men (hazard ratio [HR], 0.41; 95% confidence interval [CI], 0.34–0.50) and women (HR, 0.38; 95% CI, 0.30–0.49). Additionally, a specific threshold emerged, signifying the point at which risk reduction plateaued for all-cause mortality – established at 42 kg for men and 25 kg for women. Furthermore, a linear dose-response association materialized among participants aged 65 years or older. However, cancer mortality failed to exhibit a substantial or robust association. In conclusion, this study’s outcomes underscore an inverse dose-response connection between incremental increments of handgrip strength and all-cause mortality in older adults, pinpointing optimal handgrip strength levels at 42 kg for men and 25 kg for women. Additionally, a sustained linear association was observed among participants aged 65 years and above. These findings emphasize the significance of developing preventive strategies for older adults with diminished handgrip strength levels.
Age and Ageing
IF 2021: 12,782
López-Bueno R, Andersen LL, Calatayud J, Casaña J, Grabovac I, Oberndorfer M, Del Pozo Cruz B. 2022. Associations of handgrip strength with all-cause and cancer mortality in older adults: A prospective cohort study in 28 countries. Age and Ageing. 51(5). https://doi.org/10.1093/ageing/afac117
More information
Alex Hooshiar – axh@nfa.dk
