Repository

Revised method for the determination of N-nitrosamines

Leader(s):

Carina Engel

Institute:

IFA

Downloads:

Share:
Share on linkedin
LinkedIn
Share on twitter
Twitter
Share on email
Email
Share on whatsapp
WhatsApp
Share on print
Print

With the entry into force of the new TRGS 552 “Carcinogenic N-nitrosamines Cat. 1A and 1B”, an acceptable concentration of 0.075 μg/m3 and a tolerable concentration of 0.75 μg/m3 were established for N-Nitrosodimethylamine. To comply with these concentrations, the measurement procedure for N-nitrosamines has been completely revised in 2018.

The revised IFA method, which will be presented here, includes the analysis of seven N-nitrosamines. Sampling is carried out with Thermosorb-N-cartridges specially designed for N-nitrosamine analysis. After elution of the N-nitrosamines, the analytical determination is achieved by gas chromatography with TEA detector (Thermal Energy Analyser), which is specially designed for the analysis of nitroso compounds and implies a high sensitivity.

A essential step in complying with the acceptable concentration was the doubling of the sampling time from previous 2 hours to 4 hours. As a result, a limit of quantification of 0.010 μg/m3 per N-nitrosamine (based on a 400 L air sample) was achieved.

However, this increased sampling time implicates the problem of breakthroughs occurring at relative humidities greater than 40% and simultaneously increased N-nitrosamine concentrations in the workplace air. This concerns especially the more volatile N-nitrosamines.

In order to enable sampling at workplaces with higher humidity levels, various tests were carried out on a dynamic test gas facility. Some changes in the sampling procedure finally made it possible to measure N-nitrosamines concentration-independent also in the air humidity range of 40% to 60%, although with minor restrictions. Unfortunately, sampling at a relative humidity greater than 60% is still not possible.

Latest news

Two particular developments are salient to policymakers: Industrie 4.0 and theplatform economy.Thefirst represents the digitalisation of production, epitomised by Industrie4.0. The second involves the digitalisation of…

Newsletter

Subscribe for the newsletter and stay up-to-date

About PEROSH

PEROSH comprises 13 Occupational Safety and Health (OSH) institutes

The PEROSH partners aim to coordinate and cooperate on European research and development efforts in occupational safety and health.

PEROSH board members

Newsletter

Subscribe for the newsletter and stay up-to-date